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This fracture pattern limits the choice of implants and raises the risk of adverse outcomes.
For example, since βKlotho is primarily expressed in adipose tissue and liver, this expression pattern limits the potential target tissues for FGF21 action.
Although coiled-coils are highly structured, they should substantially differ from globular domains not only in the number of possible folds (secondary structure is restricted just to the α-helix) but also in designability: Presence of the heptad pattern limits the sequence space in comparison to an unconstrained α-helix.
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Rapid sequence diversification is consistent with only limited requirements for structure conservation and, together with high variability of gene expression patterns, limits the interpretation of any functional study focused on a single HyPRP gene or a couple of HYPRP genes in single plant species.
A high-confidence model for the core region could be identified based on disulphide connectivity, but extensive loop insertions containing cysteines with unknown disulphide bonding patterns limited the ability to generate an overall high-confidence model of TgAMA4.
However, current resistance patterns limit the use of these drugs (2 ).
Bioavailability of total and all- E-zeaxanthin in response to AMB exhibited an absorption pattern limited to the first 24 h post-test article administration followed by a decrease in blood concentrations below pre-dose levels.
Most of the existing metallization optimization methods are restricted to the conventional H-pattern, which limits the achievable improvements.
It is difficult to interpret these observations by assuming afterslip or poroelastic rebound, which reproduces the deformation pattern limited within a narrow area near the focal area.
However, the use of such fixed stimulation patterns limits hand function to the few tasks programmed into the controller.
Although such prospective, randomized trials are the gold standard for evaluating the safety and efficacy of new medical treatments, their strict designs may not reflect community practice patterns thereby limiting the generalizability of findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com