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However, another factor that may contribute to this pattern is functional pleiotropy of female-biased genes, which would limit their evolutionary potential (Parisi et al. 2004; Zhang et al. 2007).
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Due to the high degree of conservation of pattern 3 in almost every, but not all, remaining CAP families evaluated, one can certainly assume that pattern 3 is functional and that the likeliest and most reasonable function for pattern 3 is flap (by position and by motif similarity to the true empirically characterized flaps).
In fact, some studies have revealed altered β-subunit patterns in human heart failure [19], [20], suggesting that an altered β-subunit expression pattern is of functional relevance.
Nodal patterning without Lefty inhibitory feedback is functional but fragile.
The WRKY genes encoding the variant domain patterns might be functional, because 10 genes with a total of seven heptapeptide variants and two zinc-finger motif variants have sequenced ESTs, although the DNA binding capacity may be reduced [ 48].
This pattern is reflective of functional iron deficiency at the bone marrow level.
This is of particular interest since it is the first indication that the three pilus types in GBS fulfill different functions and that a particular pilus pattern is associated with specific functional features that could be relevant for pathogenesis.
This pattern is typical of type I functional divergence [ 20].
At this stage zebrafish have completed organogenesis and major behavioral patterns are already functional.
This pattern is not surprising for functional managers.
This functional pattern is also consistent with the known cytoarchitectonical similarities between the retrosplenial allocortex and limbic structures [75].
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