After verifying that it is meaningful to compare E TF and A TG across heterogeneous samples, we asked whether the samples observed with high-TF expression and high-TG activity (TF+TG+) and the biological contexts enriched with a TF+TG+ regulatory pattern were biologically meaningful.
Such changes must be further studied at the protein level to ascertain if the observed changes in mRNA translation patterns are biologically relevant.
As shown in Figure 5, the GO semantic similarity score of distinct patterns is consistently higher than the randomly generated subgraphs at all n-edge groups, suggesting that the identified subgraph patterns are biologically relevant.
Among archaeal Swiss-Prot URPs, no peptide patterns are biologically significant (p < 0.05) and all may result from the much smaller size of the archaeal section of Swiss-Prot.
Since this population firing pattern readout is thought to be the general principle for the feedforward hierarchy in the visual system, this population pattern readout is biologically plausible [23].
In particular, for the analysis of developmental gene expression patterns, it is biologically sensible when images across multiple time points are jointly accounted for, such that spatial and temporal dependencies are captured simultaneously.
Our study focused on biomarker expression in tumor cells comprising primary Gleason patterns 3 and 4. Molecular evidence suggests that tumor of Gleason pattern 5 morphology is biologically distinct from tumor of Gleason patterns 3 and 4 [ 26, 27].
Since both pathogens share similar risk factors, why this pattern should be present is biologically unclear (12, 13 ), although a recent report noted a similar pattern of concomitant increases in MRSA and decreases in VRE incidence between 1999 through 2005 (14 ).
This observation provides compelling evidence that the relationship between β4 and the expression patterns of these miRNAs is biologically driven and highly conserved.
This is biologically implausible, with pattern associators being the most typical known classifier in the cerebral cortex (Rolls 2008).
