The method is illustrated by the analysis of a historical selection experiment, carried on color pattern in rats by Castle et al.
Objectives: To assess the impact of bone growth on the flexion contracture angle at the knee, to measure the bone growth pattern in rats, and to assess the impact of immobility on bone growth.
We compared the effects of antidepressive doses of NIC, FLX and the combination of both drugs on sleep wake pattern in rats subjected to one day, one week and two weeks of administration, as well as after the withdrawal of the two-week treatment.
This point has been shown previously for mice [23], but our data now showed the same co-expression pattern in rats.
For each receptor, the alternatively spliced messenger RNAs show distinct expression patterns in rat brain, particularly in the CA1 and CA3 fields of the hippocampus.
As a real example to test our approach, we considered the dynamics of the circadian patterns in rat liver.
Therefore, in this study we used rat thyroid cells as a model to study the impact of BRAF V600E/MAPK on histone acetylation of NIS and found similar NIS promoter deacetylation patterns in rat thyroid cells and human thyroid cancer cells.
Thus when comparing gene expression patterns in rat and human cell lines one will detect significant species-specific differences in expression in 1 out of every 50 genes, with the majority of the genes demonstrating similar expression patterns.
New research now suggests a possible mechanism of action for this increase in cancer susceptibility via altered protein expression patterns in rat mammary gland tissue [ EHP 118(11):1614–1619; Betancourt et al.].
