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As the MDM2 expression pattern in normal tissues is similar in humans and mice, we generated TCR transgenic mice to study tolerance mechanisms against this TAA.
However, in the uninvolved skin of these patients, Langerhans cells were more uniformly distributed in the stratum malpighii of the epidermis, which is more similar to their distribution pattern in normal skin of healthy individuals.
Our previous finding showed a differential p16 expression pattern in normal WI-38 and SV-40 transfected immortalized WI-38 cells may result in different cell fates by which normal cells maintain viability, and the immortalized cells underwent apoptosis in response to glucose deficiency in culture medium [15].
As the antigen expression pattern in normal tissues is likely to have a major impact on T cell tolerance, it is desirable to develop models that can provide information on how the physiological expression of TAAs in normal tissues affects the development and function of TAA-specific T cells.
A small subset of the genes show a restricted expression pattern in normal tissues.
We analyzed the Beclin-1 expression pattern in normal mammary glands and malignant CMTs.
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Here, we explore the influence of network topology and patterns in normal traffic flow on the performance of the DIAMoND algorithm.
Because the honey bee genome had just been sequenced, many investigators were using microarrays to look at gene-expression patterns in normal and infected bees.
The aim of this study was to investigate the effects of an internal exposure of 131I of low absorbed doses on the gene expression patterns in normal tissues in mice.
The experiment reported in the present study examined response times and fMRI-BOLD activity patterns in normal volunteers for calculation tasks entailing addition, subtraction, multiplication and division tasks of different complexities from auditory stimulation.
Recently, CTCF was shown to play key role in maintenance of DNA methylation patterns in normal differentiated cells [30], [31].
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