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In addition, the single molecule resolution of 454 sequencing provides unprecedented information about the details of DNA methylation pattern heterogeneity in clinical samples.
This approach accounts for scenarios where sites can evolve in qualitatively different ways, i.e. follow pattern heterogeneity in addition to evolving at different rates.
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As the relevant branches characterizing differences across the trees are not inferred to involve heterotachy (Fig. 1), these dissonant results are likely explained through the accommodation of pattern heterogeneity [31] in the BayesPhylogenies analyses.
The Bulgarian, Turkish, Moroccan and Ethiopian communities show a different pattern, with heterogeneity in the pattern observed among these communities.
Breathing pattern heterogeneity did not change in relation to PEEP variation.
Furthermore, by measuring the abundance of allelic DNA methylation patterns, cellular heterogeneity in methylation patterns can now be explored [ 4].
To validate that this pattern reflects heterogeneity in sequence variation rather than problems with our pooling approach, we compared the polymorphism pattern on 3R obtained from a Portuguese D. melanogaster population to the polymorphism data generated by Sanger re-sequencing of a D. melanogaster population from The Netherlands [21].
The association is limited to obese cases, demonstrating a similar pattern of heterogeneity in allelic odds ratios to those in FTO, and warrants follow-up in replication cohorts.
Analysis at the level of households, using GIS, makes it possible to determine precisely the pattern of heterogeneity in the risk of P. falciparum infection and transmission.
In vivo measurement of hypoxia in a variety of human tumours by SPECT imaging of iodoazomycin arabinoside showed an unusual pattern of heterogeneity in GBM tumours specifically (Urtasun et al, 1996).
Furthermore, the unconstrained MANTRA analysis demonstrated greater precision for fine-mapping than the random-effect analysis (K = N), unless the pattern of heterogeneity in allelic effects between populations is poorly represented by the prior Bayesian partition model.
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