Exact(2)
The proposed tumour-dormancy-based model recognises such steps as metastatic dormant states at the single cell level and avascular micrometastasis level [ 3, 8, 14], and relates the hazard rate pattern for recurrence to the non-linear disease development.
This study reports that the kinetics of recurrence to different metastatic sites followed the same bimodal pattern for recurrence (to any site) described previously by these authors and others, with a first peak at around 2 years and a second, smaller peak at about 5 years [ 2- 6].
Similar(58)
In our data set, both stage II and III patients exhibited classical log-normal-shaped patterns for recurrence risk, so we restricted parametric examinations to the common model choices of exponential, Weibull, log-logistic, and log-normal.
In addition, we noted though that there was evidence of non-proportional hazards for the important clinical factor of stage, between stage II and III colon cancer patients (Sargent et al, 2007, 2010), both stage II and III patients exhibited classical log-normal-shaped patterns for recurrence risk.
We sought to determine whether there is, instead, a longitudinal pattern of recurrences and to identify risk factors for recurrence.
The test later classified her as low risk for recurrence.
This result has been partially anticipated [ 2] by the bimodal risk pattern for local recurrence, which may be viewed as a type of soft tissue metastasis in patients undergoing mastectomy and lacking residual breast parenchyma.
In accordance with other series, our results show that metastatic recurrence is the main pattern of recurrence for our patients and isolated locoregional recurrence occurs rarely after TME plus RT [ 1].
Pattern of recurrence for SLN-negative patients reflects previous observations (Statius Muller et al, 2002), where relapse in the previously mapped lymph node basin is rare and equally as frequent as systemic metastasis.
Pretreatment performance status, pattern of recurrence (worse for patients with anastomotic recurrence) and number of recurrent lesions (worse for patients with multiple recurrent lesions) were statistically significant prognostic factors for overall survival.
Pattern of recurrence after SABR for oligometastases confined to one organ was analyzed by Milano et al. from the University Rochester [ 41]. 73% of the patients eventually developed new metastases, most frequently occurring in the initially involved organ, but also commonly in other organs.
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