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Although genetically distinct forms of FSGS may follow different patterns of inheritance, the pattern can be difficult to identify, particularly in small families.
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The utility of these tests has been criticised because the specific biological processes responsible for the observed patterns can be difficult to tease apart [19].
Studying these haplotype patterns can be difficult with existing forward-in-time simulators because detailed information about the mosaic haplotype structure of individuals is not readily available, and must be inferred from the output sequences of the simulation and/or stored recombination event data.
"The process of uncovering relevant connections across mountains of information and the static elements that they underlie requires temporal information and event patterns, which can be difficult to capture at scale with currently available tools and systems," said DARPA program manager Boyan Onyshkevych in a news release.
However, even with a normal coronary artery pattern, coronary transfer can be difficult in some cases.
Due to their small size, lack of contrast enhancement and miliary pattern, fungal abscesses can be difficult to detect on CT images.
Proving the type of relationship two people have, and the pattern of sharing confidences, can be difficult because it often depends more on personal perception than concrete evidence.
In landscapes whose surface has been modified by terracing and other agricultural land-use, the spatial and temporal patterning of prehistoric settlement can be difficult to detect using traditional, site-orientated archaeological survey methods, especially for small-scale societies.
Obtaining information on fine-scale movement patterns and foraging behaviours can be difficult [9].
The utility of this analysis has been criticized because the specific processes responsible for the observed patterns in many cases can be difficult to tease apart [15].
This is particularly relevant for selecting a PI for salvage therapy because the clinical significance of many patterns of PI-resistance mutations can be difficult to interpret.
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