Thermal fluctuations significantly alter the oscillation pattern and induce bursts, each with a random number of spikes (red line in Figure 7c1).
Therefore, we conclude that, ECM proteins indeed modified the growth patterns and induced the osteoblast differentiation of hMSCs.
Tendon fibroblasts sense cyclic stretch in the dose- and time-dependent patterns and induce protein productions (Col-I, TGF-β1, COX, PGE2, and LTB4) (Wang, 2006).
PM bridges cause breakthrough patterns and induce transient anchoring of spiral waves.
Another possibility is that TFIIS knockdown could alter transcription patterns and induce expression of a tumor suppressor gene.
Dietary methyl deficiency (folate, choline, and methionine) in animal models alters hepatic DNA methylation patterns and induces liver cancer in the absence of a carcinogen [ 286].
Furthermore, overexpression of miR-148b and -152 in pancreatic cancer cell lines decreases DNMT1 expression, restores normal DNA methylation patterns and induces re-expression of TSGs, like BNIP3 and SPARC[ 77].
These group A and B transcription factors briefly outline the Th17-specific gene expression patterns and induce the expression of a transcription factor RORγt (Ivanov et al. 2006; Ciofani et al. 2012).
(III) Changes in the spatio temporal organization of nuclear architecture or loss of boundaries might cause altered nuclear territories, disrupt ordered epigenetic patterns and induce altered gene expression programs.
There is emerging interest in the possibility that exposure to certain xenobiotic chemicals may be obesogenic (Grün and Blumberg 2009; Holtcamp 2012; La Merrill and Birnbaum 2011) and may change growth patterns and induce weight gain, obesity, and ultimately insulin resistance and type 2 diabetes (La Merrill et al. 2013).
