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The study is investigating the relation of the ploidy pattern and cell cycle kinetics to different types of endometrial hyperplasia to select the high-risk women who will need strict follow up surveillance.
Given the vast differences between human and mouse in the development, tissue architecture (e.g., lobulation and branching pattern) and cell composition of the respiratory system, existing information in the rodents may not be directly translated into humans.
Given the huge differences between human vs. mouse of their respiratory systems in terms of developmental process, lung lobulation, branching pattern and cell composition, the identity of human lung progenitor cells need to be rigorously evaluated.
We further investigated the correlation between the ordered pattern and cell movement by examining the persistence length on each pattern in the WT STA cells.
We further asked a question regarding the temporal hierarchy between the ordered pattern and cell movement: Does a cell elongate in the direction of cell movement or move in the direction of protrusions?
Figure 1 figure supplement 2 presents the spatial pattern and cell types expressing GFP in those lines with midgut expression.
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Hobert, O. Patterning and Cell Type Specification in the Developing CNS and PNS.
The TTP complex is postulated to regulate the organization of microtubule arrays, and thus control cell division patterns and cell growth11,13,14.
An optimal collagen concentration was found for both substrate patterning and cell compatibility.
Taking advantage of this unique property of cross-linked albumin, the authors fabricated patterned cell co-cultures with desired patterns and cell types.
Localized cytoplasmic determinants packaged as ribonucleoprotein (RNP) particles direct embryonic patterning and cell fate specification in a wide range of organisms.
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