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Patients were requested to stimulate 4 h per day during the treatment period.
All patients were requested to fast for 6 h prior to the 18F-FDG injection.
Patients were requested to keep a headache diary for 1 month prior to treatment and for 3 months posttreatment.
Patients were requested to choose which of 15 pain descriptors described their typical current pain and pain at illness onset.
Patients were requested to provide personal, clinical and lifestyle information through a questionnaire and give a blood sample.
Patients were requested to complete and return them within 1 month; one reminder letter was sent to those who failed to do so.
A total of 795 patients were requested for hospitalization in GICU, while GICU stay of 55 (6.9 %) patients were rejected because of full bed occupancy.
Following treatment administration, patients were requested to make multiple assessments of pain intensity and pain relief (PAR) on the eDiary over a period of 24 h.
Initially, tissue samples from 819 patients were requested from 54 pathology laboratories throughout the Netherlands.
Moreover, patients were requested to actively flex the distal as well as the proximal interphalangeal joints (so called "clenching a small fist").
All patients were requested to collect urine for 24 h.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com