These subjects were selected from blood donors during the last two months of the patients' selection period and fulfilled the same exclusion criteria reported for the patient group.
The patients' selection of ED sites was used as the outcome variable in the logistic regression.
Incorporation of more sensitive predictive and/or prognostic molecular factors could help physicians in patients' selection.
Overall these observations provide a strong rationale for a molecular-based diagnosis and patients selection for targeted therapies.
The limitation of our study includes patients selection of cervicocephalic arterial dissection was biased because our institution mainly deals with emergency patients with severe symptoms.
This homogeneity in patients' selection was considered of great importance since RME treatment might have caused high variation in individual response.
We reviewed the literature with regard to the optimal therapeutic management of this particular population, with focus on molecular perspectives for improving patients' selection.
Another one could be the use of different patients' selection criteria, such as recruitment of university students or medical staff instead of patients who spontaneously visited a Headache Clinic, the latter experiencing more day life discomfort from their migraine.
However, although there might be some bias in patients selection, many randomized controlled trials (RCTs) and meta-analyses showed no difference in mortality between CRRT and IHD [63 65].
The latter mostly targets to patients selection for ONS: "Diagnostic criteria for rCM and guidelines for managing targets patients with rCM and selecting candidates for invasive neuromodulation are crucial issues [4]".
In this Comment Letter [3] the authors present Chronische Migrane: Therapie, Therapieresistenz und Neuromodulation – Ein Konsensus-Statement, a consensus statement on CM with and without medication overuse, therapeutic options, with particular focus on patients selection for Occipital Nerve Stimulation (ONS).
