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or "bottom-up" method (by referring to the patients sample record).
In a future work, it may be worth monitoring patients' changes over time with multiple follow-ups, also involving larger patients sample in a multicentric study.
Our results do not confirm the hypothesis that COMT rs4680 genotype influences the clinical response to triptans as previously suggested [21], albeit our study was performed on a comparable patients sample (218 vs 198 pts).
Due to the lack of published data concerning this sub-population of refractory chronic CH patients, sample size calculation was based on the estimation of characteristics of these CH patients, registered in our institution database.
Rains in his review about the "Behavioral Headache Treatment" [66] has presented a critique of methodological quality of the clinical trials literature, highlighting the strengths and weaknesses in relation to recruitment and selection of patients, sample size and statistical power, the use of a credible control, and the reproducibility of the study interventions in clinical practice.
We did not set a minimum number of patients (sample size) to be considered.
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Drug companies and universities argue that because the data they get from the patients' samples have monetary value they should not have to share it with their competitors.
For a detailed description of patients' samples, see Table 1.
IB performed patients' samples purifications.
The total number of patients sampled is.
This pooled cohort has 560 patients' samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com