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Twelve patients experienced hypersensitivity reactions, and 15 patients experienced cutaneous toxic reactions.
Six patients experienced distant failure.
Four patients experienced postoperative complications.
Five patients experienced progressive disease with sonidegib.
Eight patients experienced grade 4 toxicities.
The patients experienced "substantial" nighttime reflux, the study reported.
About half the patients experienced a mild fever.
Four patients experienced grade 4 5 late toxicities.
In comparison, treated patients experienced a decline of only 4.3%.
None of the patients experienced cancer recurrences or metastasis.
Eighteen patients experienced relapse after initial response to therapy.
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