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In addition, it has been shown that Vpr can be found in brain section of HAND patients, specifically in astrocytes and neurons [36] and neuronal cell death was observed in these patients, concomitantly with the presence of Vpr protein and transcripts [37].
Adjuvant hormone therapy, consisting of tamoxifen or aromatase inhibitors, was administered in most patients concomitantly with IMRT.
A potential better approach to overcome this toxic effect is to alkalise the urine by treating the patients concomitantly with sodium bicarbonate.
Lymph node recurrences, which were found in the paraaortic region, developed in two patients concomitantly with distant metastasis (the lungs in one, and the liver in the other), both of whom had macroscopically positive pelvic nodes.
Moreover, FMD significantly improved 1 week and 4 weeks after nCPAP in 10 male OSA patients concomitantly with an increase of plasma NOx concentrations, and a correlation between the two was observed [ 12].
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As examplified in Fig. 5, high serum levels of Nectin-4 (198 pM) and CA15.3 (151 U/ml) were detected in a patient concomitantly with the appearance of pulmonary metastasis 32 months after diagnosis (gray bars).
With regard to the patients concomitantly treated with immunomodulators, the prediction panel indicated that both the G/G genotype of rs766748 in IL17F and the C/C or C/A genotype of rs1883136 in TRAF3IP2 were strongly associated with response to IFX in the CD patients with use of immunomodulators (P = 0.0019, OR = 37.92; Table 5).
It has been theorized that DPP-4 inhibition could lead to increased events of angioedema, particularly in patients concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors (another class of agents with peptidase activity) [ 29].
CONCLUSIONS: Patients concomitantly treated with warfarin and SSRIs that are potent CYP2C9 inhibitors had comparable rates of bleeding events, ischemic or thromboembolic events, and mortality as did patients cotreated with warfarin and other SSRIs, although small but potentially meaningful effects on bleeding cannot be completely excluded.
Also of interest, in patients concomitantly treated with opioids, ketamine has been shown to increase pain relief.[34] This may suggest a role for ketamine in the treatment of medication overuse headache.
Scientists found that the one-year survival rate and tumor regression rate were both significantly higher in patients concomitantly treated with melatonin (4).
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