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AVERROES was a superiority trial in patients (n= 5599) who had failed or were unsuitable for VKA prophylaxis, comparing apixaban 5 mg (or 2.5 mg in selected patients) bid with ASA (81 324 mg per day).As with ARISTOTLE, the primary efficacy endpoint was the occurrence of stroke (ischaemic or haemorrhagic) or systemic embolism.
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Common procedures could be exposed to open market forces that set prices and allow patients to bid around those prices to achieve maximum value.
In metformin-treated patients, exenatide BID was noninferior to PIA for glycemic control but superior for hypoglycemia and weight control.
In metformin-treated type 2 diabetic patients, exenatide BID was noninferior to PIA in terms of glycemic control and superior in terms of hypoglycemia.
Overall discontinuation rates were low and similar between groups: 6% of ticagrelor 90 mg bid patients; 7% of patients receiving 180 mg bid; and 6% of patients receiving clopidogrel 75 mg qd.
Conclusion: In patients requiring FP250 bid for asthma stability, FP100/salmeterol bid was steroid-sparing, allowing a 60% reduction in the FP dose while maintaining overall asthma control.
Greater reductions in plasma HIV-1 RNA levels were also observed in patients receiving APV600/RTV BID than those using APV1200 BID.
Hypotension was also more common in ticagrelor groups, occurring in 1.2% of ticagrelor 90 mg bid patients: 3.7% of ticagrelor 180 mg bid patients and 0.6% of clopidogrel 75 mg qd patients.
Responses in the "mildly", "moderately" or "severely" disordered states were given by 16.3%, 10.0% and 2.7% of exenatide BID patients and 17.9%, 11.8% and 3.7% of insulin patients.
After 26 weeks, exenatide BID patients had lost 4.1 ± 0.22 kg of weight, while PIA patients had gained 1.0 ± 0.22 kg (LS mean ± SEM; P < 0.001 for group difference).
Responses in the "mildly", "moderately" or "severely" disordered states were given by 18.2%, 13.2% and 4.2% of exenatide BID patients and 20.8%, 14.6%, and 5.7% of insulin patients, respectively.
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CEO of Professional Science Editing for Scientists @ prosciediting.com