We then added explanatory variables at practice, doctor, and patient levels as fixed effects.
One iSNV (position 10,218) shared by 12 patients is later observed as fixed within 38 patients, becoming the majority allele in the population (Fig. 4C) and defining a third Sierra Leone cluster (Fig. 4, A and D, and fig. S8).
To compare demographic features, we conducted univariate analyses of variance (ANOVAs) for continuous variables with genotype and affection status (BD patient, relative, control) as fixed factors and chi-square tests for dichotomous variables.
The next model (M2) included patient-level variables as fixed effects only.
For analysis of differences in ADC and FA values, a multivariate ANOVA (MANOVA) was applied with the subject groups (patient vs. control) as fixed factor, the right versus left side as cofactor, and the ADC/FA values of the ROI locations as dependent variables.
This sensitivity means that nearly two-thirds of major cardiovascular events (not occurring within 30 days of implantation or within 30 days after previous hospitalization) may be predicted in conjunction with a specificity of 99.5%, equivalent to 1.83 FP alarms per patient-year, used as fixed input for the algorithm optimization procedure.
All domains were analyzed using group (patients or healthy siblings) as fixed factor and family as random effect to account for within family correlation.
Linear mixed models were adapted including profession, professional experience, type of clinic and number of THR patients within the clinic as fixed covariables.
Mathematically, the temporal evolutions of the glucose and insulin concentrations are described by a 'grey' model in form of a deterministic nonlinear dynamic system of first-order ordinary differential equations that contains patient-dependent as well as fixed parameters and functions (Figure 1).
The subject ID was modelled as a random effect, while log-transformed NK Target ratio and patient cohort were modelled as fixed effects.
