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We therefore wondered whether changes in the protein concentrations (which can be easily adjusted by an organism or result from crosstalks with other signaling pathways) would enable the required regulatory flexibility.
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It has been shown that the penetration of the CPP DNA complex did not depend on the endosomal pathway, which would enable a more prolonged effect of the DNA upon intracellular delivery due to a slower release [ 32– 32].
We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions.
If parameters can be estimated for many reactions in a pathway, it would enable inference of the target of a mutation or drug treatment – if the estimates show that one enzyme is particularly strongly affected, that enzyme is probably the target.
Further improvement of the de novo metabolic pathway reconstruction method would enable the on-demand integration of reaction network and gene (or protein) networks derived from metabolome and other omics, e.g. genome, transcriptome and proteome.
A comprehensive understanding of molecular pathways underlying GBM behavior would enable the development of targeted therapeutic approaches.
Furthermore, knowing the signaling pathways and molecular mechanisms would enable manipulating cell proliferation and optimizing its insulin secretory function.
The identification of pathways associated to resistance would enable the design of combined therapies to overcome 17AAG resistance.
House Republican leaders criticised what they called the "flawed" legislation on Wednesday, rejecting the kind of wholescale reform that would enable a pathway to citizenship for 11 million undocumented workers.
26 Collecting such data, including patient, carer and healthcare professional perspectives, during the early implementation of an integrated care pathway for end-of-life care would enable it to be refined and improved.
We hypothesized that the results of our meta-analysis would enable us to identify conserved pathways dysregulated across neurodegenerative diseases.
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