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The association of deregulated signal pathways with various diseases has long been a research hotspot.
In angiogenesis, integrins are known to regulate many cell decisions associated with this program by integrating the cellular viability pathways with various processes ranging from ECM deposition and degradation, directional endothelial cell migration and assembly into primitive cords, to lumen formation and vessel maturation [57], [58].
Furthermore, MSKE and SOD reverts EMT by targeting Snail expression, underscoring the importance of targeting these pathways with various inhibitors and antioxidants.
There are certain disparities in different population studies investigating the association of polymorphisms of genes encoding PRRs and proteins of their signaling pathways with various aspects of cancer development.
Our laboratory has developed a combinational transcriptional engineering approach to screen and select the optimal pathways from thousands of mutated fungal xylose pathways with various combinations of XR, XDH, and XKS expressions [ 6].
The issue of an association of single nucleotide polymorphisms of genes encoding C-type lectin receptors, RIG-I-like receptors, and proteins of pattern recognition receptor pathways with various features of cancer progression is open, and only further population studies would be likely to give a definite answer.
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We have found that ectopic expression of core components of the BMP pathway with various Gal4 drivers also causes similar defects and phenocopied loss of Wg signaling.
Eight equal ADMD step intervals are indicated in the folding pathway with various colors.
Next we correlated the expression of the diverse members of the EpCAM signalling pathway with various clinico-pathological patient characteristics.
All picrosides are formed from the esterification of catalpol derived from iridoid biosynthetic pathway with various aromatic acids obtained from phenylpropanoid pathway [ 7].
These in vitro studies demonstrated that AngII-induced EMT in a normal rat kidney cell line was exclusively dependent on the Ang-(1 7)/ mas receptor pathway, with various profibrotic cytokines up-regulated with Ang-(1 7) and reversed with the mas receptor antagonist A779 [ 41].
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