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This work includes the development of mechanisms for controlling the nucleation and architecture of semiflexible filaments using the design of assembly pathways with specific energy barriers.
We have demonstrated how these signaling pathways with specific sensitivity towards expression of FLO11 are integrated to respond under nitrogen starvation.
PARADIGM-Shift works best with small pathways with specific genes of interest, that is, focus genes [ 12].
However, none of these studies established associations of particular metabolites or metabolic pathways with specific somatic mutations or expression levels that have been extensively characterized in TCGA.
These changes are unevenly distributed among metabolic pathways, with specific categories of pathways being promoted to more central locations as an answer to environmental constraints.
As these regulatory pathways are often impeded on in cancer stem cells, this knowledge could offer us the possibility to directly target misregulated pathways with specific drugs.
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Ting, L.M. et al. Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins.
We conclude that members of the p24 family furnish subcompartments of the secretory pathway with specific sets of machinery cargo to provide the proper microenvironments for efficient and correct secretory protein transport and processing.
In conclusion, our data provides evidence of a role for Cldn13, and three other genes with no previous link to erythropoietic function (Cdca8, Cenpk and Cdr2), in a known stress response pathway with specific relevance in resistance to trypanosome infection and potential importance in many other contexts including acute anaemia and erythroleukaemia.
The role of PET/CT in the patient pathway, with specific comparison with triple assessment, CT, magnetic resonance imaging and MDP bone scan is addressed.
We recently showed that inhibition of the MAPK pathway with specific inhibitors could upregulate HLA class I expression on gastric and esophageal cancers.
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