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Pathways with P values < 0.01 were selected.
Canonical pathways with p < 0.05 were considered significant.
2 Pathways with P < 0.01 are listed in the table.
For the KEGG pathway analysis, pathways with p value less than 0.05 were used.
After inputting targets of a drug, hypergeometric test was performed to obtain the statistically significant enriched pathways with P ⩽ 0.05.
An example is "cancer pathways" with P values of 10−6 for the targets of preserved miRNAs and of 10−12 for targets of dysregulated miRNAs.
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Subsequently, we performed enrichment analysis for 223 FFDS targets, and pathways with P-value <= 0.01 and Fold Enrichment >= 1.5 were retained to find their relationships with pain.
The results of GO terms with P-values < 10−5 were considered to be significantly enriched, and KEGG pathways with P-values < 10−3 were considered to be significantly enriched.
The pathways with p-value <0.001 were considered as significantly enriched pathways.
Statistical significance was calculated using the Fisher's exact test, and pathways with p-values <0.05 (−log p-values) >1.3) were investigated.
TANGO [48], a resampling based method for pathway enrichment analysis (see Methods), did not find any pathways with p-value smaller than 0.48, see Table S2 for annotations with less significant p-values (DNA Replication was found in all signatures, but with a p-value higher than 0.8).
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