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In the multiple DCL protein-containing organisms such as Drosophila and A. thaliana, they function in distinct RNA silencing pathways with overlapping specificity [ 79].
We combined pathways with overlapping genes such as mitochondrial electron transport (Metacore), electron transport (Metacore) and electron transport chain (GSEA) and categorized the processes.
It is clear that pathogenesis of PKD is very complicated and involves multiple molecular pathways with overlapping, complementary, or opposing effects.
In parallel, there are pathways with overlapping functions that are not consolidated into one SuperPath.
However, because enzymatic pathways with overlapping or redundant function and other pharmacokinetic factors (e.g., blood flow limitation) can also influence metabolic fate (Kedderis 1997), PBPK models are needed to evaluate the implication of genetic polymorphisms in metabolizing enzymes in human health risk assessment (Ginsberg et al. 2010).
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PTs with no mapped genes are omitted; 2. From Reactome, extract all genes in the database and link them to their associated pathways; 3. Match the genes associated to each phenotype to their associated pathways; 4. Connect PTs with overlapping pathways with an undirected edge, setting edge weight as the number of overlapping pathways.
However, most of the brain regions and specific networks or gene modules affected similar pathways with overlap between most.
Recent advances in cell death research have changed our perception, leading us to consider these processes as interconnected with overlapping signaling pathways and cross-talk in response to different stresses.
Metabolic pathways may have common origins with overlapping substrate specificity, and so caution should be used in interpreting functional data based solely on DNA sequence analysis.
Together, these data suggest that Gcn5 affects multiple pathways, some overlapping with Elp3, and others overlapping with Mst2.
Considering the pathways that are significant according to the Hypergeometric distribution, still 24 of the 51 UC pathways are overlapping with DCM (47%).
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