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Ppargc1a transcribes the transcription factor PGC-1α and is also involved in other pathways with lower p-values.
This distinction is illustrated in the Tukey's boxplot, which shows the glutathione and respiratory chain pathways with lower and more variable conservation values than the other sub-pathways.
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Therefore, more potent analogues of curcumin that can inhibit the STAT3 pathway with lower doses are needed as a more efficient form of treatments for colorectal cancer.
Developmental biology and extracellular matrix organization were also detected as putative sperm pathways but with lower probability.
Consistent with the hypothesis that substrate availability limits the amount of AsA produced via an alternative pathway, plants with lower pectate lyase activity accumulate less AsA [ 18].
The metabolic flux and (key enzymes) genes transcriptional analysis indicated that weakened metabolic fluxes in organic acids (especially butyrate) formation and re-assimilation pathways, which associated with lower buk and ctfAB transcriptional levels, contributed to higher butanol and lower acetone production rate in fermentations on cassava.
The expression of both proteins decreases after birth and in the cochlea of E18.5 embryonic Igf1−/− null mice, the balance of the main IGF related signalling pathways is altered, with lower activation of Akt and ERK1/2 and stronger activation of p38 kinase.
In vivo, membrane-mediated fibril formation can provide an alternative pathway, with potentially lower barriers for fibrillization.
A possible explanation might be that PgR expression is promoted by ER and may thus identify a subgroup of DIN with a less activated ER pathway with the lower sensitivity to endogenous hormones (Decensi et al, 2012).
Two secondary metabolite pathways with Q values lower than 0.05 were identified as terpenoid backbone biosynthesis (75 DEGs) and phenylpropanoid biosynthesis (163 DEGs).
There were three pathways with Q value lower than 0.05 in the amino acid metabolism sub-category, which included phenylalanine metabolism (92 DEGs), alanine, aspartate and glutamate metabolism (80 DEGs) and valine, leucine and isoleucine biosynthesis (45 DEGs).
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