Sentence examples for pathways with improved from inspiring English sources

Therefore, the quest for novel antiplatelet agents simultaneously targeting the three pathways with improved efficacy/safety profile is of immense importance.

The development of biosynthetic pathways with improved propanol yields, the breeding or identification of microorganisms with higher propanol tolerance, and the engineering of propanol producer strains that efficiently utilize low-cost feedstocks are the major challenges on the way to industrially relevant microbial propanol production processes.

The annotation of enriched targets with pathways gave improved insight into understanding the MOA of the phenotype, underlining the signalling pathways involved in cytotoxicity.

A recent example of complex, multistep pathway optimization is seen with improving levopimaradiene production in E. coli [ 80].

Blocking the antiapoptotic IGF-1R pathway with AG1024 improves apoptosis induction over the level due to treatment with gefitinib alone (Fig. 3).

Moreover, if the structure of the metabolic and regulatory networks and their component genes yielded relatively few genetic pathways with which to improve growth on glucose, it is unlikely that the multi-step mutational pathway to Cit+ that first required mutations that improve acetate utilization would ever have been realized.

Importantly, inhibition of the PI3K pathway was substantially improved with the BKM120-PD0325901 combothtinn, both in vitro and in vivo, as evidenced by a more complete suppression of p-S6.

The four patients with an ejection fraction <50%, two of whom had left lateral pathways, improved to >50% after ablation.

Transcription factor modulation coupled with rational tuning of the cellobiose consumption pathway significantly improved cellobiose fermentation.

"Many groups around the world are pursuing their own research pathways to develop improved models".

For over a decade preclinical progress in cancer biology, genetics, tumor profiling, and biotechnology have led to the successful development of a greatly expanded spectrum of biologically active agents that effectively target cancer-related proteins and pathways that improve individual antitumor effects with decreased toxicity for selective patients.