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It is initially investigating all 14 cancer pathways, with each examined by a cancer specialist, GP, senior nurse, cancer manager and other support staff, and will remain in place "until all aspects of the incident are resolved and ongoing action plans agreed".
(We note a similar finding in the companion study [28] using a different methodology: RRMS and SPMS share more dysregulated gene ontology pathways –principally immune regulation pathways– with each other than with PPMS).
One model to explain the suppression of fat-6;fat-7 by nhr-64 is that the two are acting in parallel pathways, with each pathway having an opposite effect on the fat storage/fat oxidation balance.
This is in agreement with previous work that has associated these pathways with each of the diseases [ 12, 28- 31].
Interestingly, spleen and gut tissue, which are closely associated during gastrointestinal development [ 72] share more similar pathways with each other than with vertebral column tissue.
As a result of incorporating pleiotropic terms, 32 additional annotations were added to 25 pathways, with each pathway receiving between one and three terms.
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The significance of the association of a pathway with each trait was evaluated using the hypergeometric test.
The health risk for adult and children is considered separately since the contact pathway with each exposure way changes with age.
We show that HLH-29 can regulate the transcriptional activity of the IP3 signaling pathway genes ppk-1, ipp-5, and plc-1 and provide evidence that hlh-29 acts in a genetic pathway with each of these genes.
Moreover, Tap42-Sit4, whish is the upstream regulator of Gcn4, is indirectly regulated by TORC1. Figure 6 illustrates this signaling pathway, with each element annotated using its information flow rank.
We simulated the evolution of a 5-gene pathway, with each gene as its own TU, in a population of size N for 1 generations across values of ncDNA (L) ranging from 1to 1 and binding site size (n) ranging from 10−20 (prokaryotes) and 6−10 (eukaryotes), under models of binding site mutation (gain/loss) and genetic drift.
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