Sentence examples for pathways which resulted from inspiring English sources

DOX-EPNs entered into resistant tumor cells by multiple endocytosis pathways, which resulted in overcoming the multidrug resistance of MCF-7/Adr cells by escaping the efflux induced by P-gp transporters.

We showed that Chidamide was able to increase the acetylation levels of histone H3 and to inhibit the PI3K/Akt and MAPK/Ras signaling pathways, which resulted in arresting colon cancer cells at the G1 phase of the cell cycle and promoting apoptosis.

RUT exerts different mechanisms to modulate signaling pathways, which resulted in different cell fates with diverse cell types and growth conditions [ 34].

Goel et al (2004) reported that interactions between the IGF-1R and β1 integrins also activated signalling through both the PI3 kinase and MAP kinase pathways, which resulted in enhanced prostate tumour cell migration on and invasion through the extracellular matrix (Goel et al, 2004).

Unsupervised hierarchical clustering of all cell line data and data from 84 osteosarcoma biopsies (GEO accession number GSE33382, [ 9]) was performed on all DE genes present in these 17 significantly affected pathways, which resulted in a cluster of control cells and biopsies, and larger cluster of osteosarcoma cell lines and biopsies (Additional file 4).

We observed in the present study that the expression of MnSOD was upregulated by BTG2 at the transcription level via degradation of IκBα in cancer and normal cells, and that underlying mechanism of APRO effect of BTG2 involved the crosstalk between PI3K-Akt1 aNFκBFκB pathways, which resulted in the scavenge of ROS and increased p21WAF1 expression.

The structured surfaces can form a liquid vapor conversion system which consists of cavities as stable cavity-centric vaporization cores and interconnected grooves as the cooling water supply pathways, which results in significant heat transfer enhancement and CHF increase.

We found that (1) SARS-CoV PLpro-TM inhibits the activation of transcription factor IRF3 and negatively modulates the IFNβ signaling pathways, which results from PLpro-TM impeding STING- and TBK1-activated phosphorylation and dimerization of IRF3.

Vitamin B12 deficiency leads to the impairment of these pathways, which results in accumulation of MMA and Hcy, megaloblastic anemia and central nervous system abnormalities.

In transformed cells, Met activation triggers several signaling cascades, such as the mitogen-activated protein kinase (MAPK) and AKT pathways, which result in proliferation, invasion, and/or prevention of apoptosis.

The genetic alterations acquired by tumors modify their biochemical pathways, which results in abnormal tumor metabolism.