Sentence examples for pathways which function from inspiring English sources

Our foot in the door has been the study of the cyclooxygenase-2 (COX-2) pathway and its downstream prostaglandin receptor signaling pathways, which function in important ways in modulating the inflammatory response in brain in models of Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and stroke.

Altered pathways in primary tumor were Wnt, JAK-STAT, cell cycle and focal adhesion pathways, which function in tumor initiation and development.

This article identifies a specific negative regulatory mechanism for the Notch and Wg pathways, which functions at the level of endocytic vesicles.

Oxidative stress can be triggered by several factors, including a malfunction of the pentose phosphate pathway, which function to regenerate NADPH for recycling the oxidized glutathione [ 41].

We also asked whether CPY* aggregates activate the ERSU pathway, which functions to ensure the inheritance of functional cER (Babour et al., 2010).

Our studies in the mouse model of mucopolysaccharidosis type IIIB, a lysosomal storage disease that induces neurodegeneration, showed that large storage vesicles in cortical neurons did not receive material from either the endocytic or autophagy pathway, which functioned normally.

Tumor sections from xenografted tumor spheres were stained using an antibody against β-catenin, which is a key regulator of the Wnt pathway which functions in controlling stem cell self-renewal.

Meanwhile, we specifically investigated the cAMP signaling pathway, which functions in parallel with the MAPK cascade.

The NET is an important component of the noradrenergic pathway which functions to reuptake NE into the presynaptic terminals.

The Ras GTPase pathway, which functions downstream of VEGF, is active during development of normal or pathological vascular networks.

The mechanism of the WBC pathway, which functions in several larval developmental decisions, is similar to the well-described vertebrate Wnt/β-catenin signaling pathway.