Sentence examples for pathways which contributes from inspiring English sources

Our findings indicate that RAGE preferentially binds to mutant KRAS to activate the RAF-MEK-ERK and PI3K-AKT pathways, which contributes to HIF1 α activation in vitro and in vivo.

Hybrid molecules synthesized by fusing or conjugating different active molecules obtained from these sources are reported to synergistically block different pathways which contribute in the pathogenesis of complex diseases.

Signaling pathways which contribute to regulation of Oct4 stability and transactivation have not been identified previously; indeed, this area remains a conspicuous "black box" in our understanding of the circuitry which controls pluripotency.

In contrast, in pre-eclamptic women, a condition characterised by chronic placental hypoxia, the contractions of labour could exacerbate the effect of hypoxia leading to an increased release of activin A. However there could be additional pathways which contribute to the plasma levels.

Likewise, EPA appears to act on several direct and indirect pathways, which contribute to muscle wasting and muscle anabolism.

Binding of secreted FGFs with heparan sulphate proteoglycans enables signalling through receptor tyrosine kinases to activate MAPK and PI3K/AKT pathways which contribute to tumour growth and angiogenesis [ 67].

Therefore, we suggested that Wnt signaling be one of the most important pathways which contributed to the improved proliferation capacity of CIKIL-15.

Aging research on P. anserina and other model systems involves the identification of cellular pathways which contribute to an increased functional period of time ('healthspan') [ 3, 6].

It is likely that many genes and pathways which contribute to defects in PAA remodelling are yet to be discovered, given the complexity and lack of complete understanding of this developmental process.

The additive effect of erk5 gene deletion with inhibition of ERK1/2 and PKB signaling in vitro suggests that ERK5, ERK1/2 and PKB are components of independent pathways which contribute to the survival of sympathetic neurons via overlapping mechanisms.

OPN binds to several cell surface receptors and induces several signal transduction pathways, which contribute to tumorigenesis by the inhibition of apoptosis or the activation of matrix-degrading proteases [ 45].