Sentence examples for pathways which contribute from inspiring English sources

Hybrid molecules synthesized by fusing or conjugating different active molecules obtained from these sources are reported to synergistically block different pathways which contribute in the pathogenesis of complex diseases.

Signaling pathways which contribute to regulation of Oct4 stability and transactivation have not been identified previously; indeed, this area remains a conspicuous "black box" in our understanding of the circuitry which controls pluripotency.

In contrast, in pre-eclamptic women, a condition characterised by chronic placental hypoxia, the contractions of labour could exacerbate the effect of hypoxia leading to an increased release of activin A. However there could be additional pathways which contribute to the plasma levels.

Likewise, EPA appears to act on several direct and indirect pathways, which contribute to muscle wasting and muscle anabolism.

Aging research on P. anserina and other model systems involves the identification of cellular pathways which contribute to an increased functional period of time ('healthspan') [ 3, 6].

It is likely that many genes and pathways which contribute to defects in PAA remodelling are yet to be discovered, given the complexity and lack of complete understanding of this developmental process.

Therefore, we suggested that Wnt signaling be one of the most important pathways which contributed to the improved proliferation capacity of CIKIL-15.

Our findings indicate that RAGE preferentially binds to mutant KRAS to activate the RAF-MEK-ERK and PI3K-AKT pathways, which contributes to HIF1 α activation in vitro and in vivo.

It might be activated via class I PI3-K-Akt pathway which is sensitive to growth factors and transduces signal to activate cell growth and proliferation [ 17, 27] or by Raf-1-MEK1/2-ERK1/2 pathway, whicontributeuto to amino acid depletion-induced autophagy [ 2, 28].

The complementary evidence indicated that ROS generation is associated with the activation of the JNK pathway, which contributes to PARP and caspase-3 activation after exposure to ZnO NPs.

Oncogenic K-Ras stimulates activation of the Akt/mTOR pathway, which contributes to the development of lung tumors [6], [7].