Sentence examples for pathways which activate from inspiring English sources

One potential explanation for the upregulation of anti-inflammatory type 2 cystatin proteins in prostatitis is the body's attempt to regulate the inflammatory response and prevent excessive tissue destruction, similar to the case of activation of hemostatic pathways, which activate fibrinolytic proteins to prevent excessive clotting.

In experimental models of brain ischemia, post-stroke infections have been associated with the activation of the autonomic nervous system and neuroendocrine pathways, which activate anti-inflammatory signaling pathways, including IL-10 [ 20].

In this regard, MRP4 has been involved in signalling pathways which activate prosurvival mechanisms by virtue of its capability to pump cyclic nucleotides outside the cells [ 11].

It can be suggested that SMAD-independent pathways, which activate proinflammatory proteins and transcription factors such as JNK, p38, and NF- κB, are able to reprogram macrophages to the M1 phenotype, particularly when the SMAD-dependent pathway is blocked.

9 All TLR (except TLR3) as well as interleukin (IL) 1 and IL-18 signal via MyD88-dependent pathways, which activate nuclear factor kappa B-driven pro-inflammatory signalling.

There is currently a great deal of interest in the manner in which cell senescence may contribute to age-associated loss of function or age-related pathology in vivo, and molecular studies are directed towards elucidating mechanisms and pathways which activate the senescence program in cells [ 6].

Taken together, these results indicate that LPS-TLR4 complex formation is one of the major pathways, which activates the NF-κB and PI-3K pathways in chondrocytes.

Wnt signaling has several molecular pathways: the canonical Wnt pathway, which requires β-catenin, and the noncanonical Wnt pathways, which activates downstream signaling independent of β-catenin [ 19, 20].

There are, he said, more than 10 IRS proteins in the insulin signaling pathway, which activate PI3K, producing phosphatidylinositol (3 5 -trisphosphate, as well as activating the Akt family.

Previous studies, all in Sigma, had shown that the adhesion phenotype was controlled by the filamentation mitogen-activated kinase (fMAPK) pathway, which activates a set of transcription factors required for the transcription of the structural gene FLO11.

This decrease in oxygen causes activation of the hypoxia inducible factor (HIF) pathway, which activates the transcription of many genes that cause cell proliferation, metastasis, increased glycolysis and angiogenesis.