ER signaling is still active (partly due to the release of its inhibition by AKT), while the apoptosis and proliferation pathways are partially active.
Yet, it is also possible that both pathways are partially interconnected downstream of Amotl2a.
It has been proposed that siRNA and miRNA pathways are partially overlapping and few factors participate in both the pathways.
In the mutants, signalling pathways are partially uncoupled, demonstrating dominance of metabolic control of photoreaction centre expression over sensing the redox state of the PQ-pool.
Expression of genes involved in cell death pathways was partially restored by treatment, while genes involved in differentiation, cell cycle and growth were not affected.
Again similar to S. cerevisiae, recruitment pathways are partially redundant: the Taz1 Rap1 interaction is compensated by a second Taz1-dependent pathway that nucleates methylation of H3K9 by Clr4 (Kanoh et al, 2005).
These changes in glycolytic pathway were partially confirmed using colorimetric methods (Figs S2 C E).
By contrast, if the Mmi1 pathway were partially compromised, Ccr4-Not should become more important and its inactivation would lead to increased levels of Mmi1 targets.
These results argue that PI3K/AKT pathway is partially dependent on TGFA/EGFR signaling, an observation that could have important implications in developing therapeutic PTC compounds directed against targets other than the MEK/ERK pathway.
Thus, the IIS pathway is partially active in the absence of Lnk.
