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In addition, connections between Asc1p and signaling pathways were only recently established.
Rho-kinase Ca2+-sensitization and Ca2+-influx pathways were only significantly activated in PA.
Complete pathways were only found for the biosynthesis of folate and possibly riboflavin.
In addition, melanogenesis and axon guidance pathways were only detected in hOFs, consistent with hOFs being derived from cranial neural crest cells.
Additionally, cancer census genes [ 45] and genes that were part of known cancer-relevant signaling pathways were only significantly overrepresented in GBM IV.
In contrast, it was observed that the VEGF and PDGF signaling pathways were only significantly upregulated in early CAN/IFTA compared to Banff 0 biopsies and IGF1 was the only significant growth factor pathway upregulated in moderate/severe CAN/IFTA.
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Most of the copy number variations (CNV), MYC translocations and somatic mutations in MAPK, NF-kB, and DNA repair pathways are only seen at MM stages and not in pre-malignant stages and are therefore potential secondary events.
Particular PTD transformation pathways are only mentioned in cases where an analytical confirmation of specific reaction steps and products exists.
Interestingly, cells deficient in both pathways are only partially defective in heterochromatin silencing, which suggests other factors might also be involved (Huang et al., 2007).
One protein's presence can have a drastic effect on a multitude of proteins and pathways and the interrelationships between seemingly unrelated proteins and pathways is only now coming to light [10].
On the other hand, the retention of normal contrast sensitivity and near-normal optokinetic acuity under photopic conditions indicates that cone pathways are only minimally affected.
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