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In addition, network analysis also revealed that different innate immune pathways were linked together by calcium-activated transcription factors.
The laboratory studies identified that the leptin signaling pathways were linked to the pathophysiology of AD.
The human pathways were linked to form a network (see Methods section) where each pathway is a node.
Pathways were linked to one another if one or more protein pairs between the two pathways were predicted to interact.
Defective Rsp5/NEDD4 pathways were linked to α-synucleinopathy, which was supported by genetic screening in yeast (27, 29).
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A major question in the field is whether PINK1-dependent pathways are linked to pathways mediated by other PD-linked genes.
In contrast, peripheral alpha- and beta-adrenoceptor-related signaling pathways are linked to up-regulating processes.
Although considerable data have demonstrated that suppression of the insulin/IGF-1 and mTOR signaling pathways are linked to lifespan extension, the underlying mechanisms remain elusive.
The behavioral overlap of co-morbid diagnoses is due to the widely distributed networks with which central auditory pathways are linked, in bottom-up, top-down, and reciprocal loop processes [5].
It is currently unknown if the two pathways are linked.
While many T cells pathways are linked to known immune/inflammatory networks, the majority of the top B cell pathways are linked to cell growth, survival and metabolism.
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