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All pathways were converted into graphs with compounds as nodes and reactions as edges.
All of the modules and pathways were converted to flat gene sets, so intra-pathway gene-level interaction data were not used.
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A fine, heterogeneous mosaic of small patches (with many possibilities for migration pathways) was converted into large, homogeneous blocks.
Although the physiological functions of TOL and ILA remain unknown, it is possible that intermediates of IAA biosynthesis pathways are converted into these storage compounds whenever necessary (Cassán et al. 2014).
In this model, pathways are converted to an equivalent BN logic gate.
In [ 31] the metabolic pathways are converted to a simple network of enzymes/genes.
Both the KEGG and Reactome maps also lack significant additional information about pathway entities (e.g., PubMed IDs, supportive references) and neither is readily amenable to computational analysis approaches unless their pathways are converted to standard file formats that can be imported to analytic tools such as Cytoscape.
The random walk starts with equal probability from each of the genes in the target set and the generated relevance scores obtained for the nodes of the reference pathways are converted to distance scores by subtraction from 1, resulting in a distance score vector for each pathway.
To complete the metabolic cycle of SAH, the common product homocysteine of the two degradative pathways is converted to methionine by a homocysteine methyltransferase (MetE, 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase or MetH, 5-methyltetrahydropteroyltriglutamate homocysteineerase), then to SAmethyltransferasese (MetK).
The results indicate that 1 can be oxidized to its related o-benzoquinone (1a) and without conversion to its quinone methide tautomeric form, via an ECEC mechanism pathway, is converted to barbiturate derivatives (5a b).
3,4-Dihydroxy-2-butanone 4-phosphate of pentose phosphate pathway is converted to 6,7-Dimethyl-8 ribityllumazine by Rv1416 (RibH).
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