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Along the same lines, a few links belonging to canonical pathways were added to the network, if the pathways were reported to be directly involved in pluripotency.
Additional pathways were added after a team discussion.
Several alternative carbon metabolism pathways were added to the Shewanella models based on literature data [ 3] and our experimental observations.
At this time, DDC, H2O2, catalase, vitamin E or inhibitors for signalling pathways were added (t=0 h).
Plant specific metabolic pathways were added as supplementary resource using the latest PlantCyc database files (release 6.0) [ 19].
Doxycycline, an antibacterial with anti-inflammatory effects, gained traction as a therapy for DED when inflammatory pathways were added to the understanding of dry eye pathogenesis [ 5].
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We propose that specific molecular networks are established early in T cell activation and then additional and critical gene components of these pathways are added as a function of time to obtain and/or regulate the impact of these networks on the final result.
In the future, as more reliable insect pathways are added to iPathDB, we will carry out insect pathway conservation analysis.
The search procedure continues interactively until no qualified pathways can be found.As shown in Figure 2A, MCR in general drops quickly at the beginning and becomes flat when more pathways are added to the collaborative set.
For example, although PLS ranked consistently near the bottom in the internal validation, it showed a steady decrease in accuracy rank in the external validation as more pathways are added to the classifiers, yielding a medium average rank of 3.3.
Within the formed network, we observe that lineage-specific pathways are added to the core component of the network in two characteristic ways: with direct links, or the formation of peripheral extensions.
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