Sentence examples for pathways we designed from inspiring English sources

To disrupt these oncogenic metabolism pathways, we designed an LXR inverse agonist SR9243 that induces LXR-corepressor interaction.

In order to gain insight into disease mechanisms and the biological processes underlying the response to infection, and to identify the genes and genetic variants controlling these pathways, we designed a family-based genetic study of phenotypes related to infection with P. falciparum.

To find potentially regulated paths between different pathways, we designed a method based on non-redundant shortest paths in a weighted graph.

To verify if a similar effect could be identified in the processing of plasmid DNA ends by the two DSB repair pathways, we designed an assay in which the levels of HR and NHEJ can be assessed in parallel.

To develop HPRT-based DSBR assays that do not rely on introducing an I-SceI site into the genome, and to compare I-SceI and CRISPR-induced DSBR pathways, we designed four exon 6-specific guide RNAs for the Cas9 nuclease of Streptococcus pyogenes: two (gRNA-1 and -2) targeting wild-type HPRT alleles and two (gRNA-3 and -4) targeting I-SceI-sensitive HPRT alleles (Fig.  7A).

To develop more effective inhibitors than fosmidomycin, a natural compound which inhibits the deoxyxylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the MEP pathway, we designed molecules possessing on the one hand a catechol that is able to chelate the magnesium dication and on the other hand a group able to occupy the NADPH recognition site.

However, though the pathway we designed is absence of any feedback loops, it is still perfectly adaptive because of its nonlinear properties.

To determine the relationships among these three genes in the PCD signaling pathway, we designed epistasis experiments combining transient overexpression and silencing of combinations of these genes.

In order to verify the biological significance of the effect of all treatments on the oxidative phosphorylation pathway, we designed a study to evaluate the effects of exposure to a series of doses of Ag+ on embryo oxygen consumption.

To test our model for the order of action of genes in a regulatory hierarchy that governs the Wnt10b/β-catenin signalling pathway, we designed an epistatic functional assay for WNT10B.

To further investigate the potential mechanisms underlying the role of Wnt/β-catenin pathway in apoptosis, we designed an oligonucleotide microarray covering 1384 apoptosis-related genes.