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It is well known that other pathways in addition to the MAPK cascade, such as the PI3K/AKT pathway, play a role in oncogenesis in melanoma, and inhibition of multiple pathways was shown to be synergistic in melanoma cell lines [38].
The expression of genes from these pathways was shown to be lowered by flax cannabinoids in previous microarray studies.
14 Activation of the PERK-eIF2α axis of the UPR pathways was shown to upregulate Atg12, convert LC3-I to LC3-II, and subsequently lead to autophagosome formation.
Moreover, the safe elimination of toxins via GST pathways was shown to protect cellular DNA against reactive oxygen species (ROS -induced damage [ 36].
The gene-pathway bipartite network, which connected the 29 DEGs with the 20 cancer-related KEGG pathways, was shown in Figure 1.
The gene-pathway bipartite network of 62 DEGs connected to the 20 cancer-related KEGG pathways was shown in Figure 3.
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The top 10 enrichment pathways are shown in the senior bubble chart.
The two experimentally determined structures of the transition pathways are shown with larger point sizes.
Plausible reaction mechanisms for key pathways are shown.
KEGG pathways were shown in two heatmaps.
Proteins of the specific pathways are shown column-wise.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com