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To develop a new strategy, the effect of overexpression of the squalene biosynthesis (SB) pathway and squalene overproduction on the ethanol production (EP) and post-squalene biosynthesis (PB) pathways was determined in Saccharomyces cerevisiae.
Activation of preferential flow pathways was determined from the sequences of soil moisture responses at various depths for a total of 633 water input events, including 82 irrigation events.
Enrichment of genes associated with specific canonical pathways was determined relative to the Ingenuity knowledge database for each of the individual platforms and the integrated analysis at a significance level of p<0.01.
The activation of the MAP Kinase pathways was determined by blotting for phospho-SAPK/JNK (Fig. 1A) and phospho-p38 (Fig. 1B), and the degradation of IκBα was indicative of the activation of the NF-κB pathway (Fig. 1C).
Enzyme-coding genes were identified and their role in KEGG enzymatic pathways was determined.
When the LNCaP cells were treated with recombinant midkine, activation of intracellular signalling pathways was determined by Western blot analysis.
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To assess some of the direct effects on proximal tubular cells, changes in gene expression of selected cellular pathways were determined after exposure to angiotensin II.
Subsequently, the fault propagation pathways from the downstream backwards to upstream process are isolated through the variable contribution indices and hence the ending nodes of the identified pathways are determined as the root-cause variables of the abnormal events.
Indeed, multiple cell cycle pathways were determined to be significant using Metacore pathway analysis (Table 4).
Using this software and its accompanying interaction database, top-ranked pathways were determined based on the incidence of predicted miRNA targets in a list of canonical pathways provided by the software.
Overrepresented cancer stage-specific pathways are determined.
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