The order in which the transition pathways are conducted is random for each time-step.
The co-expression analyses on other ESC-critical pathways were conducted in the same way as on the cell cycle.
Signaling pathways were conducted by using KEGG database.
Furthermore, analysis of the feedback structures, which is also very common in signaling pathways, is conducted as an expansion to an original structures without feedback.
The majority of in vitro studies concerning the effects of Mn on cell signaling pathways were conducted in cell culture models [ 23, 39].
Much of the analysis of metastasis pathways is conducted in tightly controlled in vitro cell systems, usually involving overexpression or ablation of a particular gene.
We also tested a similar approach in which a literature-derived network of biological relationships is first assembled and subsequently, an exhaustive search for sub-networks representing particular pathways is conducted (26).
As such, no comparison across the entire AFL participation pathway was conducted.
Inhibition of the classical pathway was conducted as previously described by Palarasah et al. [28].
