Twelve pathway developers (8 GPs, 4 cardiologists) and four pathway users consented to conducting face-to-face interviews.
The evaluation of the pathway was conducted in a qualitative design on a sample of 12 pathway developers (8 GPs and 4 cardiologists) and 4 pathway users (GPs).
Within the context of the feasibility study, we asked all 12 pathway developers (8 GPs and 4 cardiologists) and the 6 pathway users, familiar with the pathway recommendations, to participate in our qualitative evaluation study.
Our qualitative study was part of a larger feasibility study [ 30] with 18 GPs in three study arms (8 pathway developers, 6 pathway users, 6 control group) and 290 consecutively recruited patients with CHD.
In the case of the xenobiotics biodegradation reference pathway, users should use the compound to undergo biodegradation as a query, while in the case of the reference pathway of biosynthesis of secondary metabolites the query should be the end product of biosynthesis.
For other types of IDs (for instance, Affymetrix microarray probe set IDs) not included in the common ID lists, Pathview's auxiliary functions will map user data to pathways when users provide the ID mapping data manually.
Kvik Pathways allows users to interactively explore a molecular dataset, such as gene expression, through a web application.
The platform also provides diverse customized tools, such as gene knockouts and the introduction of heterologous pathways, for users to reconstruct the model network.
EXPath offers gene general information including descriptions, cDNA and protein sequences, Pfam protein families, GO terms, and involved pathways for users' reference.
