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Studies indicate the meiotic spindle serves as an architectural element in the egg that acts to colocalize elements from several of the key signaling pathways and may provide a means for these pathways to interact.
The secret seems to lie in the capacity of the pathways to interact with each other and generate a varied array of outputs.
Curcumin protected HUVECs cells from oxidative stress by inducing autophagy via pI3K/Akt/mTOR and FOXO pathways to interact with Atg7; the involvement of FOXO (a mediator of autophagy) was confirmed in a knockdown study in which autophagy was inhibited by an siRNA.
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One other study has attempted to look at how pathways fear to interact.
Several pathways seem to interact for the final outcome of the disease.
Spry1 has been found to inhibit DNA damage response pathways, and to interact with and stimulate cell cycle progression factors such as Cdk1.
Curcumin, a bioactive component of turmeric, has been proposed to modulate multiple cell signaling pathways and to interact with numerous molecular targets, including cell cycle, apoptosis, proliferation, angiogenesis, and inflammation [ 1].
In contrast, combining endocrine agents with newer targeted agents (e.g., everolimus) to block cell signaling pathways known to interact with the estrogen receptor provided increased clinical benefits versus endocrine monotherapy [ 4, 7].
One pathway known to interact with Rho in mammalian cells is the Ras/ERK/MAPKinase pathway [60], [61], [62].
Specifically this context involved how the various elements of the clinical pathway needed to interact to enhance the performance of the clinical system as a whole.
Therefore, it appears that aberrant phosphorylation by oncogenic kinases could interfere with the tumor suppressor activities of SOCS1 by at least two different mechanisms: phosphorylated SOCS1 would not be able to inhibit the JAK/STAT pathway and to interact with ATM and promote p53 activation.
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