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Using a genetic map with an estimated 20,000 genes, researchers expected to be able to target particular traits expressed in individuals and use genetic pathways to identify and manipulate specific genes that were responsible for the trait.
Rogers et al[152] used the information of potential metabolic pathways to identify the correct molecular formula.
The bottom-up approach uses discovery metabolomics, cell culture and animal models, GWAS or other genomics data as well as metabolism pathways to identify substrate candidates for specific transporters.
The knowledge derived may be employed by skilled practitioners in defining career pathways, to identify where, when and how to update their skillsets in line with advancing technology and changing work demands.
These CHO mutants have been used to characterize glycosylation pathways, to identify genes that code for glycosylation activities, to elucidate functional roles of glycans that mediate biological processes, and for glycosylation engineering.
For example, to build upon the observation that some cancer cells seem addicted to particular nutrients, such as specific amino acids, Ryder depends upon his team's knowledge of the biochemical processes that occur as nutrients enter the cell, including the key intermediates and enzymes in pathways, to identify proteins that could serve as potential drug targets.
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It can open powerful pathways to identifying and resolving health system challenges, and as such is a crucial ingredient for any health system strengthening effort [ 21].
We explored structural regions outside the putative serotonin translocation pathway to identify potential binding sites for allosteric transporter modulators (ATMs).
Hence, NREL researchers began to look for key enzymes in the lipid synthesis pathway to identify the critical factor for controlling oil production in algae.
KOBAS software was used to test the statistical enrichment of DEGs in KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway to identify markedly enriched metabolic pathways or signal transduction pathways compared with the whole genome background.
We compared the issue conditions for each pathway to identify those pathways that are preferentially used to support the processing of care versus justice issue dilemmas.
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CEO of Professional Science Editing for Scientists @ prosciediting.com