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Simultaneously, reduced growth rate of CaZF expressing mutant cells in comparison to the wild type cells expressing the plant gene also evokes a possibility that CaZF may require both the pathways to function in its full strength.
We suggest that the first metazoans must have had a way of controlling their internal milieu in order for signal transduction pathways to function, and that a sealed epithelium was therefore one of the first defining features of multicellular animals.
Biological systems utilize highly complex, interrelated networks and pathways to function and in contrast to our previous work [19], here we used two complementary computational systems biology modeling approaches: Gene Ontology (GO; [24]) –based and canonical genetic-network-based, to derive understanding from our large dataset.
The overshoot allows for gene products being available in large amount for multi-step pathways to function, and it can also act as a dominant source of large deterministic variability paving way to increase the phenotypic diversity of a population of cells before the negative regulation sets in.
Biological systems utilize highly complex, interrelated metabolic and signaling pathways to function.
The amount of specific proteins translated is critical for biological pathways to function optimally in response to environmental perturbations.
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The current knowledge on the biological function of the implicated genes, which vary from WNT4 and FN1 in developmental pathways to functions of VEZT, GREB1, ID4, NFE2L3, FN1, ETAA1 and CDKN2B-AS1 in carcinogenesis, is described below.
Growing human embryonic stem cells in the presence of BIO allows the Wnt pathway to function fully.
"When you eliminate the ability of this pathway to function, you don't make a tail, and instead you make a new head".
By systematically inhibiting specific RNA molecules and then revving up the Hedgehog pathway, the researchers could see whether a gene was necessary for the pathway to function.
The decrease in biocatalyst function would not allow for the biochemical pathway to function properly, adequately sequestering glucose as glycogen when glucose levels are high and degrading glycogen when glucose levels are low.
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