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Solid tumors can hijack these formidable pathways to construct a microenvironment highly unfavorable to anti-tumor T lymphocytes able to recognize them, one of mechanisms for their immune evasion.
Among these cellular genes, we summarized the interactions between nodes in these enriched KEGG pathways to construct a combined pathway network.
Previously, cellobiose phosphorolytic pathways were combined with xylose isomerase pathways to construct anaerobic cellobiose and xylose co-fermentation systems in Saccharomyces cerevisiae and in Escherichia coli[ 16, 17].
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Indubitably this methodology gives a facile and straightforward pathway to construct benzimidazole amine hybrid derivatives in an eco-friendly fashion.
In this paper a complete pathway to construct a constitutive model well suited for finite element analysis of viscoelastic media undergoing large deformation and damage is described.
Additionally, NAD+ kinase or soluble transhydrogenase was overexpressed in BLdtugp24, which can reroute glucose metabolic flow from the EMP pathway to the PP pathway, to construct BLdtugp34N or BLdtugp34U, respectively.
We systematically analyzed the phenotypic diversity of a signaling response that results from domain recombination by using 11 proteins in the yeast mating pathway to construct a library of 66 chimeric domain recombinants.
After that, we used the dysregulated genes in each dysregulated pathway to construct a sub-model to predict the bone metastasis risk separately.
We also retrieved 714 protein-protein interactions among the 102 proteins and 195 TFs from BioGRID database to be the candidate signaling pathway to construct the signaling regulatory pathway.
Therefore, we can use the dysregulated genes in each pathway to construct one sub-model, and then integrate all sub-models into an ensemble model (DPBM) to predict the bone metastases risks of breast cancer patients by majority voting strategy.
Therefore, dynamic models were used to prune the candidate gene regulatory network and the candidate signaling regulatory pathway to construct the integrated cellular network via microarray data under the specific condition of interest.
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