Sentence examples for pathways to ameliorate from inspiring English sources

This approach could introduce an enriched potentially therapeutic subpopulation of autologous cells or of cells genetically modified to target specific macrophage pathways to ameliorate fibrosis induction or to induce fibrosis resolution.

Thus besides providing an understanding of the molecular and cellular pathways whereby oligomeric Aβ conveys toxic effects and impairs neuronal function, this study further opens opportunities to target the NADPH oxidase pathway to ameliorate the Aβ effects.

Therefore, we asked whether the Dll1-Notch1 axis regulates the myogenic potential of murine and human MABs and how to tune this pathway to ameliorate in vivo MAB-driven regeneration.

As a result, there is considerable interest in the therapeutic potential of selective small molecules to manipulate these pathways in order to ameliorate disease [ 4].

These results suggest that autophagy is less protective alone and synergistic activation of multiple neuroprotective pathways is crucial to ameliorate neurodegeneration in ALS.

This finding indicates that a differentiated and mature neural population in the spinal cord is capable of re-engaging in developmental pathways, presumably attempting to ameliorate the conditions of the damaged spinal cord and compensate for the lack of inputs.

For example, the relatively low influence of parameters pertaining to the killing of encephalitogenic CD4Th1 cells by regulatory CD8 T cells suggested a considerable redundancy in this regulatory pathway's ability to ameliorate autoimmune behavior.

Therefore, a concerted strategy that targets the nuclear Abl and the Stat-1 pathways may be required to ameliorate nephrotoxicity associated with platinum-based cancer therapy.

Furthermore, we show that a physiologically significant stress response pathway can be leveraged to ameliorate the folding defects caused by ΔF508 in vivo.

Our quantitative analysis of the craniofacial skeleton examines the effects of a HH pathway agonist shown previously to ameliorate brain abnormalities in a mouse model of DS (Roper et al., 2006; Das et al., 2013).

In addition, the results suggest that elucidating the mechanism by which p50 and p52 DNA binding changes over time may potentially uncover novel pathways that can be targeted to ameliorate specific age-related diseases.