Sentence examples for pathways the use from inspiring English sources

In addition to their utility in the unraveling of metabolic pathways, the use of mutants in the early 1940s led to the postulation of the one gene-one enzyme hypothesis by the Nobel Prize winners George W. Beadle and Edward L. Tatum; their discoveries opened the field of biochemical genetics and first revealed the nature of the fine controls of metabolism.

Culture methods for the enhancement of isolated primary hepatocytes or HLCs in vitro include the addition of GFs, TFs, and cytokines, the activation of signaling pathways, the use of an optimized matrix, and co-culture with various nonparenchymal cells.

While it is currently known that insulin deficiency in T1D has profound effects on many metabolic pathways, the use of large scale metabolic profiling in revealing these altered networks has not been fully explored in humans.

Pig physiology closely resembles human physiology, thus given the lack of porcine-specific pathways the use the human pathways information and extrapolation of these pathways for the pig can be expected to provide biological meaningful results [ 76].

Because normal and tumor stem cells often share common pathways, the use of drugs that target specific stem cell pathways is both a powerful strategy and a great challenge.

The present study revealed the molecular basis for SMAD4-dependent and -independent differences in PDAC tumor biology with the aim of identifying the subset of patients likely to respond to therapies targeting the TGF-β or EGFR signaling pathways The use of model system illustrated here may help to identify additional nodes of therapeutic intervention in PDAC patients devoid of SMAD4.

Beginning with a section on Drosophila genetics, the volume continues with parts exploring molecular and cell biological studies of the Hippo pathway, the use of structural biology and biochemistry, and a brief look at the Hippo pathway in mouse models.

Rather than using conventional manufacturing pathways, the researchers are using inkjet printing, allowing for scalable and cost-sensitive deployment.

More serious interactions happen when multiple substances work on the same biochemical pathways or use the same enzymes in the liver and kidneys.

Genes and metabolites were mapped onto the KEGG pathways using the PaintOmics3 (http://bioinfo.cipf.es/paintomics/) according to the developer's instructions50.

The figure was generated from the KEGG pathways using the enrichment protocol by GeneTrail tool.