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When orthology information is added to pathways, the same process can be represented in different organisms.
In several pathways the same reactions are active during the whole IDC (e. g. ubiquinone biosynthesis and terpenoid biosynthesis).
Paths-based approaches only partly infer cyclic or spiral-shaped pathways (the same enzymes acting repeatedly on a growing chain, e.g. fatty acid biosynthesis).
For other signaling pathways, the same situation is also observed where different databases are reconstructing the signaling pathways on their own way.
In summary, this study highlights challenges in managing clusters of resistant K. pneumoniae infections and demonstrates that, despite a lack of obvious transmission pathways, the same strain can persist in hospital environments for months, sporadically causing disease.
Linking gerontology and diabetology, the hyperfunction theory suggests that aging is not caused by damage but instead is driven by signal transduction pathways, the same pathways that are involved in age-related diseases.
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In order to evaluate if sildenafil effects were mediated by PI3K pathway, the same experiments were performed in the presence of LY294002, a PI3K inhibitor.
In our case, if two pathways have the same frame-id value, regardless of the database, then this frame-id refers to the same pathway.
If the pathways are the same length, then when the two waves meet, they add, doubling the wave amplitude.
Indeed, it is possible to have two different enzyme pathways within the same bacterium.
Some environmental factor is, or many environmental factors are, interacting with certain gene types, yielding who knows how many different pathways to the same disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com