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The genes affected by these changes belonged to a number of canonical pathways, the most prominent ones are implicated in schizophrenia and related disorders.
As for KEGG pathways, the most DEGs were enriched in translation (40 genes), followed by the carbohydrate metabolism (35 genes), amino acid metabolism (29 genes), and lipid metabolism (23 genes).
Among p53-dependent pathways, the most important are those mediating cell cycle arrest and apoptosis.
Among cell signalling pathways, the most strongly disturbed was Wnt signalling, with 34 genes including 19 pathway target genes affected.
Although our results are consistent with multiple possible exposure pathways, the most probable is exposure to contaminated dust.
These downstream proteins mediate the activation of several signalling pathways the most significant of which are the PI3K/Akt and the RAS/RAF/MAPK pathways.
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For the TGF-β pathway, the most important components are selected and listed in Table 4.
In the PTS pathway, the most significantly downregulated gene was SSU05_1490/SSU98_1501 (BgIF).
The CCmedian group revealed overexpression of genes involved in insulin signaling pathway, the most representative being IGFBP3, IGFBP5 and PIK3R1.
The ERK1/2 pathway, the most studied mammalian MAPK pathway, is dysregulated in approximately one-third of all human tumors including uterine fibroids.
"Impressively, the cardiac excitation-contraction coupling pathways are the most conserved pathways in all of animals," said Prof Block.
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