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In this review, we will outline pathways critical to HNSCC oncogenesis and highlight signaling nodes within these pathways that represent biomarkers for prognosis and potential targeted therapies.
Our study illustrates how different areas can have long groundwater pathways that represent different LULC than what can be seen on the landscape today.
It has been shown that mutant p53 triggers different pathways that represent the molecular basis of the gain of function activity [52].
This study investigated liver regeneration through a computational model involving archetypal signaling pathways that represent classes of molecular signaling.
Some general pathways are, e.g., metabolic pathways, signaling pathways or regulation pathways that represent minimal functioning units of a cellular system.
Here, we provide an overview of the metabolic pathways that represent anti-cancer targets and the cell death pathways engaged by metabolic inhibitors.
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The result is a global, interconnected network of pathways that represents the functional cross-talk within the molecular system.
Among the identified signatures, we observed the down-regulation of RNA polymerase functions and histone expression and the up-regulation of the TP53/CDKN1A-related pathway that represent interesting pathways to explore in the future, owing to their possible involvement with a decrease in the accumulation of autoantigens and the activation and proliferation of autoreactive T and B lymphocytes.
This cluster defines a KEGG super-pathway that represents a number of signalling networks directly connected to effectors functions of direct relevance with tissue morphogenesis such as Actin remodelling and Cell communication.
We have previously demonstrated that APP/sAPP α can antagonize the activation of the c-Jun N-terminal kinase (JNK) pathway that represents a central stress signaling pathway and critical upstream modulator of the mitochondrial pathway of apoptosis.
The Krebs cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the citric acid cycle, is a crucial metabolic pathway that represents a key part of aerobic respiration in cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com