Sentence examples for pathways that impact from inspiring English sources

The balance between cell survival and death is essential for cancer formation and is determined by several key pathways that impact on different stages of gene expression.

Thus, here we provide for the first time an overall analysis of the signaling pathways that impact on pou3f4 expression, acting separately over distinct enhancers located at different HCNRs.

In light of previous reports that Y4 agonism with PP mediates effects on appetite and energy balance by actions within the brainstem to modulate digestive processes via vagal cholinergic pathways [25], [29], the ability of Y4 receptor agonism with PP to influence multiple central and peripheral pathways that impact on energy homeostasis makes Y4 agonists attractive potential anti-obesity agents.

Various TME components and signaling pathways that impact cancer metastasis have been targeted.

We determined the activities of selected signaling molecules and pathways that impact PC function.

Thus, ΔNp63 α seems to act as an integrator of multiple signaling pathways that impact on cell migration and invasion.

To confirm that it was truly inhibition of the Src pathway that impacted lateral line migration, we used CRISPR/ Cas9 to target src or a downstream substrate of src, tks5a.

Functional studies indicate that a noncoding SNP associated with FOXO3A influences a cytokine inflammatory pathway that impacts outcome, not only in Crohn's but also other diseases such as rheumatoid arthritis and malaria.

Our approach exemplifies how chemical biology can be applied to a physiologically relevant experimental system with a functional readout to identify DYRKs as a novel and druggable pathway that impacts Treg cell differentiation.

We have proposed here that infection may be another relevant unfavorable condition that could trigger an anti-aging, cellular maintenance program, whether through a pathway that impacts the IIS pathway, through a damage-sensing circuit (similar to the DNA repair response pathway), or through some other uncharacterized pathway.

These results identify critical pathways that can impact lung growth arrest, as seen in CLD, and uncover novel mechanisms that could promote alveolarization, thus pointing the way toward new treatments to improve the outcomes of infants with CLD.